Transcriptomics,Multiomics

Dataset Information

3

Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life


ABSTRACT: Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. Here we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. While adult CD8+ T cells differentiated into a heterogeneous pool of effector and memory cells, neonatal CD8+ T cells preferentially gave rise to short-lived effector cells and exhibited a distinct gene expression profile. Surprisingly, impaired neonatal memory formation was not due to a lack of responsiveness, but instead because neonatal CD8+ T cells expanded more rapidly than adult cells and quickly became terminally differentiated. Collectively, these findings demonstrate that neonatal CD8+ T cells exhibit an imbalance in effector and memory CD8+ T cell differentiation, which impairs the formation of memory CD8+ T cells in early life mRNA profiles of effector CD8+ T cells from neonatal and adult mice

OTHER RELATED OMICS DATASETS IN: PRJNA243939

ORGANISM(S): Mus musculus  

SUBMITTER: Andrew W Grimson   Erin M Wissink  Andrew Grimson 

PROVIDER: E-GEOD-56575 | ArrayExpress | 2014-05-13

SECONDARY ACCESSION(S): GSE56575SRP041011PRJNA243939

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-56575.BAM.SRR1220943.bam Bam
E-GEOD-56575.BAM.SRR1220943.bam.bai Bam
E-GEOD-56575.BAM.SRR1220943.bam.prop Bam
E-GEOD-56575.BAM.SRR1220944.bam Bam
E-GEOD-56575.BAM.SRR1220944.bam.bai Bam
Items per page:
1 - 5 of 16
altmetric image

Publications

Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.

Smith Norah L NL   Wissink Erin E   Wang Jocelyn J   Pinello Jennifer F JF   Davenport Miles P MP   Grimson Andrew A   Rudd Brian D BD  

Journal of immunology (Baltimore, Md. : 1950) 20140521 1


Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. In this article, we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. Whereas adult CD8+ T cells differentiated i  ...[more]

Similar Datasets

2014-01-01 | S-EPMC4065808 | BioStudies
2015-01-01 | S-EPMC4649632 | BioStudies
2016-01-01 | S-EPMC5069106 | BioStudies
2021-11-08 | GSE159686 | GEO
2021-11-08 | GSE159685 | GEO
2021-11-08 | GSE159684 | GEO
2021-11-08 | GSE159687 | GEO
2013-01-01 | S-EPMC3771883 | BioStudies
2016-01-01 | S-EPMC5201096 | BioStudies
2019-01-01 | S-EPMC6832862 | BioStudies