Transcriptomics

Dataset Information

296

Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life


ABSTRACT: Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. Here we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. While adult CD8+ T cells differentiated into a heterogeneous pool of effector and memory cells, neonatal CD8+ T cells preferentially gave rise to short-lived effector cells and exhibited a distinct gene expression profile. Surprisingly, impaired neonatal memory formation was not due to a lack of responsiveness, but instead because neonatal CD8+ T cells expanded more rapidly than adult cells and quickly became terminally differentiated. Collectively, these findings demonstrate that neonatal CD8+ T cells exhibit an imbalance in effector and memory CD8+ T cell differentiation, which impairs the formation of memory CD8+ T cells in early life mRNA profiles of effector CD8+ T cells from neonatal and adult mice

ORGANISM(S): Mus musculus  

SUBMITTER: Andrew W Grimson   Erin M Wissink  Andrew Grimson 

PROVIDER: E-GEOD-56575 | ArrayExpress | 2014-05-13

SECONDARY ACCESSION(S): GSE56575SRP041011PRJNA243939

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications

Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.

Smith Norah L NL   Wissink Erin E   Wang Jocelyn J   Pinello Jennifer F JF   Davenport Miles P MP   Grimson Andrew A   Rudd Brian D BD  

Journal of immunology (Baltimore, Md. : 1950) 20140521 1


Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. In this article, we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. Whereas adult CD8+ T cells differentiated i  ...[more]

Similar Datasets

| GSE80597 | GEO
2015-09-24 | E-GEOD-65921 | ArrayExpress
2015-09-24 | E-GEOD-65920 | ArrayExpress
2015-09-24 | E-GEOD-66650 | ArrayExpress
2015-09-24 | E-GEOD-65922 | ArrayExpress
| GSE73459 | GEO
2009-06-24 | E-GEOD-15750 | ArrayExpress
2016-08-22 | E-GEOD-83978 | ArrayExpress
| GSE109753 | GEO
| GSE110030 | GEO