Transcriptomics

Dataset Information

3

UV Photoprotection and Long-lasting Pigmentation from UVA and/or UVB


ABSTRACT: To test whether there is a photoprotective benefit after different types of suberythemal repetitive UV, a 1.5 MED challenge dose was applied 1 week after the initial 2 weeks of repetitive irradiation.  To determine what different mechanisms and/or factors might be involved in physiological pigmentary responses of the skin to different types of UV, we used whole human genome microarrays and immunohistochemical analyses to characterize human skin in situ to examine how melanocyte-specific proteins and paracrine melanogenic factors are regulated by repetitive exposure to suberythemal doses of different types of UV (UVA and/or UVB). Seven volunteers with skin type II-III were irradiated with UVA, UVB or UVA+UVB radiation for 2 weeks (5 times per week, 10 times total) after preliminary determination of their MEDs. A UVA+UVB challenge dose of 1.5X the MED was applied 1 week later.  Biopsies were taken before the challenge dose, immediately after the challenge dose, 4 days after the challenge, and 15 weeks after the challenge.   

ORGANISM(S): Homo sapiens  

SUBMITTER: Sergio G Coelho   Julio C Valencia  Christoph Smuda  Vincent J Hearing  Ludger Kolbe  Lanlan Yin  Vincent J. Hearing  Dominik Ebsen  Andre Mahns 

PROVIDER: E-GEOD-56754 | ArrayExpress | 2014-12-12

SECONDARY ACCESSION(S): GSE56754PRJNA244657

REPOSITORIES: GEO, ArrayExpress

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Publications

UV exposure modulates hemidesmosome plasticity, contributing to long-term pigmentation in human skin.

Coelho Sergio G SG   Valencia Julio C JC   Yin Lanlan L   Smuda Christoph C   Mahns Andre A   Kolbe Ludger L   Miller Sharon A SA   Beer Janusz Z JZ   Zhang Guofeng G   Tuma Pamela L PL   Hearing Vincent J VJ  

The Journal of pathology 20150217 1


Human skin colour, ie pigmentation, differs widely among individuals, as do their responses to various types of ultraviolet radiation (UV) and their risks of skin cancer. In some individuals, UV-induced pigmentation persists for months to years in a phenomenon termed long-lasting pigmentation (LLP). It is unclear whether LLP is an indicator of potential risk for skin cancer. LLP seems to have similar features to other forms of hyperpigmentation, eg solar lentigines or age spots, which are clinic  ...[more]

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