Transcriptomics

Dataset Information

64

Gene expression profiles of induced cardiomyocytes(iCMs)


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Satoshi Kondo  

PROVIDER: E-GEOD-56913 | ArrayExpress | 2014-07-03

SECONDARY ACCESSION(S): GSE56913PRJNA244922

REPOSITORIES: GEO, ArrayExpress

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Publications


Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by overexpression of cardiac transcription factors or microRNAs. However, induction of functional cardiomyocytes is inefficient, and molecular mechanisms of direct reprogramming remain undefined. Here, we demonstrate that addition of miR-133a (miR-133) to Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Mesp1 and Myocd improved cardiac reprogramming from mouse or human fibroblasts by directly repressing Snai1, a master regulat  ...[more]

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