Transcriptomics

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Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]


ABSTRACT: The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent. In total 60 arrays

ORGANISM(S): Mus musculus  

SUBMITTER: L Rieswijk   Linda Rieswijk 

PROVIDER: E-GEOD-57082 | ArrayExpress | 2015-05-18

SECONDARY ACCESSION(S): GSE57082PRJNA245526

REPOSITORIES: GEO, ArrayExpress

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Publications

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.

Rieswijk Linda L   Brauers Karen J J KJ   Coonen Maarten L J ML   van Breda Simone G J SG   Jennen Danyel G J DG   Kleinjans Jos C S JC  

Mutagenesis 20150514 6


Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However, the complex mechanisms by which NGTX carcinogens act are less clear and may result in conflicting results between species [e.g. Wy-14,643 (Wy)]. We hypothesise that common microRNA response pathways exist for each class of carcinogenic agents. Therefore, this study compares and integrates mRNA and microRNA expression profiles following shor  ...[more]

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