Transcriptomics

Dataset Information

297

Transcriptome data of CD34+ human cord blood-derived cell treated with UM171, SR1 or both


ABSTRACT: mRNA profiling of CD34+ human cord blood-derived cell treated with UM171, SR1 or both mRNA profiles of CD34+ human cord blood-derived cell treated with DMSO (control), SR1 [500nM], UM171 [35nM] or combination SR1 [500nM]+ UM171 [35nM] for 30min, 3hr, 12hr, 24hr, 48hr, 72hr were generated by deep sequencing

ORGANISM(S): Homo sapiens  

SUBMITTER: Iman Fares   Guy Sauvageau 

PROVIDER: E-GEOD-57299 | ArrayExpress | 2014-10-21

SECONDARY ACCESSION(S): SRP041675GSE57299PRJNA246215

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon rec  ...[more]

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