Transcriptomics

Dataset Information

0

Calcitriol deregulates AR signaling to inhibit prostate cancer progression in the TRAMP model


ABSTRACT: The mechanism of action of vitamin D in prostate cancer (PCa) remains poorly defined, with most mechanisms identified being highly cell type and model specific. One of the underlying factors for these diverse mechanisms may be the use of overly simplistic in vitro model systems to study the complex biology of vitamin D response. Here we use the more complex and in vivo transgenic adenocarcinoma of mouse prostate (TRAMP) model to better determine the mechanism by which vitamin D inhibits PCa growth. In these studies early stage TRAMP mice were treated ± 20μg/kg calcitriol (vitamin D) on a Monday/Wednesday/Friday schedule and tissue was procured 12 and 24 hours post treatment to assess changes in PCa transcriptomes using Affymetrix gene expression arrays. 15 total samples were analyzed. 10 week old TRAMP mice were treated IP ± 20 ug/kg calcitriol on a Monday/Wednesday/Friday (MWF) schedule, and prostate tissue was procured 12 (N=3, control; N=4, calcitriol) and 24 hours (N=4, control; N=4, calcitriol) post treatment for use in affymetrix studies.

ORGANISM(S): Mus musculus  

SUBMITTER: Mike T Moser  Jason S Kirk   Song Liu   Barbara A Foster   Ellen Karasik   Dan Wang   Bryan Gillard    

PROVIDER: E-GEOD-57382 | ArrayExpress | 2015-03-02

SECONDARY ACCESSION(S): GSE57382PRJNA246371

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2015-08-01 | E-GEOD-64656 | ArrayExpress
2015-08-01 | E-GEOD-60956 | ArrayExpress
2008-12-31 | GSE10525 | GEO
| PRJNA246371 | ENA
| GSE61829 | GEO
2009-01-14 | E-GEOD-10525 | ArrayExpress
2011-06-15 | E-GEOD-29956 | ArrayExpress
| GSE34072 | GEO
| GSE53975 | GEO
| GSE106885 | GEO