Transcriptomics,Genomics

Dataset Information

301

Molecular architecture of transcription factor hotspots in early adipogenesis


ABSTRACT: Here, we have used digital genomic footprinting to precisely define protein localization for several adipogenic transcription factors at a genome-wide level. In combination with ChIP-seq data, these analyses reveal novel molecular insight into the organization of transcription factors at hotpot regions, which provides a new framework for understanding transcription factor cooperativity on chromatin. Digital genomic footprinting and gene expression in 3T3-L1 pre-adipocytes by high throughput sequencing.

ORGANISM(S): Mus musculus  

SUBMITTER: Susanne Mandrup   Albin Sandelin  Gordon L Hager  Ole N Jensen  Myong-Hee Sung  Rasmus Siersbæk  Ronni Nielsen  Sofie Traynor  Atefeh Rabiee  Songjoon Baek  Nicholas Clark 

PROVIDER: E-GEOD-57415 | ArrayExpress | 2014-05-08

SECONDARY ACCESSION(S): SRP041765GSE57415PRJNA246418

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications


Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic footprinting to precisely define factor localization at a genome-wide level during the early phase of 3T3-L1 adipocyte differentiation, which allows us to obtain detailed molecular insight into how transcription  ...[more]

Similar Datasets

2011-03-22 | E-GEOD-27826 | ArrayExpress
2014-04-17 | E-GEOD-56872 | ArrayExpress
2013-08-01 | E-GEOD-49423 | ArrayExpress
2010-07-06 | E-GEOD-17977 | ArrayExpress
2019-07-20 | E-MTAB-6646 | ArrayExpress
2014-05-02 | E-GEOD-56688 | ArrayExpress
2009-01-29 | E-GEOD-14004 | ArrayExpress
2011-09-02 | E-GEOD-31867 | ArrayExpress
2010-09-30 | E-GEOD-20696 | ArrayExpress
2010-09-30 | E-GEOD-21365 | ArrayExpress