Dataset Information


Molecular architecture of transcription factor hotspots in early adipogenesis

ABSTRACT: Here, we have used digital genomic footprinting to precisely define protein localization for several adipogenic transcription factors at a genome-wide level. In combination with ChIP-seq data, these analyses reveal novel molecular insight into the organization of transcription factors at hotpot regions, which provides a new framework for understanding transcription factor cooperativity on chromatin. Digital genomic footprinting and gene expression in 3T3-L1 pre-adipocytes by high throughput sequencing.

ORGANISM(S): Mus musculus  

SUBMITTER: Susanne Mandrup   Albin Sandelin  Gordon L Hager  Ole N Jensen  Myong-Hee Sung  Rasmus Siersbæk  Ronni Nielsen  Sofie Traynor  Atefeh Rabiee  Songjoon Baek  Nicholas Clark 

PROVIDER: E-GEOD-57415 | ArrayExpress | 2014-05-08



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Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic footprinting to precisely define factor localization at a genome-wide level during the early phase of 3T3-L1 adipocyte differentiation, which allows us to obtain detailed molecular insight into how transcription  ...[more]

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