Transcriptomics

Dataset Information

4

Genes expression of cervical squamous cell carcinoma, CaSki cells, treated with or without recombinant TGF-b1 (2 ng/mL)


ABSTRACT: Aggressive local invasion is the major way of spread in uterine cervical squamous cell carcinoma (CSCC). Although TGF-b facilitates invasion of various types of cancer cells, the role of TGF-b pathway in CSCC is unclear. Through array-based analysis, immunohistochemical staining of human endometrial cancer tissue, it is shown that interaction between CSCC cells and surrounding cancer asscocited fibroblasts (CAFs) activates TGF-b via TSP-1 secretion to facilitate CSCC invade, resulting in up-regulation of pSMAD3 in CSCC cells to promote invasion. These results suggest that activation of TGF-b induced by the interaction between CSCC cells and CAFs could play a key role in the initiation of tumor spreads. We used microarrays to clarify the changes of gene expression along with recombinant TGF-b1 treatment and to confirm whether there are any changes on genes expression related to TGF-b pathway.

ORGANISM(S): Homo sapiens  

SUBMITTER: Budiman Kharma   Junzo Hamanishi  Michikazu Nagura  Masafumi Koshiyama  Ryusuke Murakami  Noriomi Matsumura  Kaoru Abiko  Ken Yamaguchi  Masaki Mandai  Susan K Murphy  Tsukasa Baba  Ikuo Konishi 

PROVIDER: E-GEOD-57441 | ArrayExpress | 2014-05-09

SECONDARY ACCESSION(S): GSE57441PRJNA246462

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2015-08-27 | E-GEOD-66412 | ArrayExpress
2015-08-27 | E-GEOD-66359 | ArrayExpress
2015-08-27 | E-GEOD-66361 | ArrayExpress
2018-11-04 | PXD010164 | Pride
2013-12-31 | E-GEOD-40266 | ArrayExpress
2014-03-01 | E-GEOD-54716 | ArrayExpress
2010-09-01 | E-GEOD-23833 | ArrayExpress
2018-08-21 | GSE83834 | GEO
2014-11-08 | E-GEOD-40266 | ExpressionAtlas
2014-03-01 | E-GEOD-54715 | ArrayExpress