Transcriptomics

Dataset Information

34

Complement Roles Revealed by Immune Gene Profiling in Endometriosis and Endometriosis-Associated Ovarian Cancer


ABSTRACT: Mechanisms of immune dysregulation against established tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear cell ovarian tumors may partly derive from endometriosis, a commonly diagnosed chronic inflammatory disease. We performed here the most comprehensive immune gene expression analysis of pelvic inflammation in endometriosis and endometriosis-associated ovarian cancer (EAOC). RNA was extracted from 120 paraffin tissue blocks comprising of normal endometrium (n=32), benign endometriosis (n=30), atypical endometriosis (n=15) and EAOC (n=43). Serous tumors (n=15) were included as non-endometriosis associated controls. The immune microenvironment was profiled using Nanostring and the nCounter® GX Human Immunology Kit, comprising probes for a total of 511 immune genes. Please note that 3 normal endometrium samples did not pass the array quality filtering and therefore excluded in the data analyses.

ORGANISM(S): Homo sapiens  

SUBMITTER: SungHwan Kim  Anda M Vlad    

PROVIDER: E-GEOD-57545 | ArrayExpress| 2015-01-10

SECONDARY ACCESSION(S): GSE57545PRJNA247492

REPOSITORIES: GEO, ArrayExpress

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Publications

Complement pathway is frequently altered in endometriosis and endometriosis-associated ovarian cancer.

Suryawanshi Swati S   Huang Xin X   Elishaev Esther E   Budiu Raluca A RA   Zhang Lixin L   Kim SungHwan S   Donnellan Nicole N   Mantia-Smaldone Gina G   Ma Tianzhou T   Tseng George G   Lee Ted T   Mansuria Suketu S   Edwards Robert P RP   Vlad Anda M AM  

Clinical cancer research : an official journal of the American Association for Cancer Research 20141007 23


Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian tumors partly derive from endometriosis, a commonly diagnosed chronic inflammatory disease. We performed here a comprehensive immune gene expression analysis of pelvic inflammation in endometriosis and endometriosis-associated ovarian cancer (EAOC).RNA was extracted from 120 p  ...[more]

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