Dataset Information


Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes

ABSTRACT: We report the profiling of induced mRNA transcripts in two C. elegan replicate populations -- WT (N2) and mutant strain with deficient HLH30. Both strains were fed either OP50 strain of e-coli (normal feed) or S. aureus Examination of infected versus uninfected wildtype and mutant lawns of animals

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Javier Irazoqui   Lynda Stuart  Javier E Irazoqu  Lyly Luhachack  Sid Labed  Nnamdi Ihuegbu  Amanda Wollenberg  Orane Visvikis  Gary Stormo  Anna-Maria Alves 

PROVIDER: E-GEOD-57739 | ArrayExpress | 2015-06-04



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Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.

Visvikis Orane O   Ihuegbu Nnamdi N   Labed Sid A SA   Luhachack Lyly G LG   Alves Anna-Maria F AF   Wollenberg Amanda C AC   Stuart Lynda M LM   Stormo Gary D GD   Irazoqui Javier E JE  

Immunity 20140529 6

Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation of the transcription factors involved. By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense. HLH-30 was activated shortly after Staphylococcus aureus infection, and drove the expression of close  ...[more]

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