Dataset Information


Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin [human cell line gene expression]

ABSTRACT: There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin resistance. Although the exact mechanism remains unknown, it has been proved that insulin resistance is correlated to low heat shock protein (HSP) expression. We reveal that intranuclear insulin can reduce HSP DNA methylation level to up-regulate HSP protein expression and result in long term cure of hyperglycemia. Insulin resistance HepG2 cell were selected in our experiments.Three conditions were compared with three replicates each. These are:(1) Insulin resistance HepG2(R-HepG2) (2) Insulin treated HepG2(Insulin); (3) Biomineralized insulin treated HepG2 (BI).

ORGANISM(S): Homo sapiens  

SUBMITTER: Ruikang Tang  Zheng Li   Yiyu Cheng   Yun Xiao    

PROVIDER: E-GEOD-57893 | ArrayExpress| 2014-06-03



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