Transcriptomics

Dataset Information

247

Long-range chromatin interactions in mouse embryonic stem cells identified by ChIA-PET [ChIA-PET]


ABSTRACT: The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of cell identity genes and repression of genes encoding lineage-specifying developmental regulators. Here we use large ESC cohesin ChIA-PET datasets and other genomic data to identify the local chromosomal structures at both active and repressed genes across the genome. The results show that super-enhancer driven cell identity genes generally occur within large loops that are connected through CTCF-CTCF interaction sites occupied by cohesin. Smc1 ChIA-PET data from wild type murine embryonic stem cells V6.5 were generated by deep sequencing using Illumina Hi-Seq 2000.

ORGANISM(S): Mus musculus  

SUBMITTER: Keji Zhao   Lyndon Zhang  Brian J Abraham  Zi Fan  Denes Hnisz  Jill Dowen  Richard A Young  Tong I Lee  Gang Ren 

PROVIDER: E-GEOD-57911 | ArrayExpress | 2014-06-27

SECONDARY ACCESSION(S): GSE57911SRP042202PRJNA248406

REPOSITORIES: GEO, ArrayExpress, ENA

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