Dataset Information


Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress

ABSTRACT: Gene expression profile in CS1AN deficient and CSBwt restored cell lines after 24 hours of UV or alphe-amanitin treatment (only for restored). The comaprison of expression profile between 0 and 24 hours revealed continouse suppresion of transcription upon UV treatment in CS1AN cell line and alpha-amanitin treated CS1AN CSBwt restored cells. Gene expression profiles were obtained in duplicates for un-treated (assigned as 0h time point) and treated (assigned as 24h time point) cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Alexey Epanchintsev   Jean-Marc Egly  Egly Jean-Marc 

PROVIDER: E-GEOD-57923 | ArrayExpress | 2014-05-23



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Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.

Kristensen Ulrik U   Epanchintsev Alexey A   Rauschendorf Marc-Alexander MA   Laugel Vincent V   Stevnsner Tinna T   Bohr Vilhelm A VA   Coin Frédéric F   Egly Jean-Marc JM  

Proceedings of the National Academy of Sciences of the United States of America 20130603 25

Cockayne syndrome type B ATPase (CSB) belongs to the SwItch/Sucrose nonfermentable family. Its mutations are linked to Cockayne syndrome phenotypes and classically are thought to be caused by defects in transcription-coupled repair, a subtype of DNA repair. Here we show that after UV-C irradiation, immediate early genes such as activating transcription factor 3 (ATF3) are overexpressed. Although the ATF3 target genes, including dihydrofolate reductase (DHFR), were unable to recover RNA synthesis  ...[more]

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