Transcriptomics

Dataset Information

2

Effects of CBD on the glioma stem cell molecular signature


ABSTRACT: Primary glioma stem cells cultured as neurospheres in NBL media with growth factors were subjected to treatment with the non-toxic, non-psychoactive cannabis compound cannabidiol (CBD). Control and CBD- treated cultures were used to generate RNA used to hybridize on Affymetrix DNA arrays Fluorescence intensities data were RMA-normalized using Partek software.

ORGANISM(S): Homo sapiens  

SUBMITTER: Liliana Soroceanu   Saleena Ghanny 

PROVIDER: E-GEOD-57978 | ArrayExpress | 2015-04-17

SECONDARY ACCESSION(S): GSE57978PRJNA248643

REPOSITORIES: GEO, ArrayExpress

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Publications

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma.

Singer E E   Judkins J J   Salomonis N N   Matlaf L L   Soteropoulos P P   McAllister S S   Soroceanu L L  

Cell death & disease 20150115


Glioblastoma (GBM) resistance to therapy is the most common cause of tumor recurrence, which is ultimately fatal in 90% of the patients 5 years after initial diagnosis. A sub-population of tumor cells with stem-like properties, glioma stem cells (GSCs), is specifically endowed to resist or adapt to the standard therapies, leading to therapeutic resistance. Several anticancer agents, collectively termed redox therapeutics, act by increasing intracellular levels of reactive oxygen species (ROS). I  ...[more]

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