Dataset Information


Gene transcript alterations exhibited in luminal and basal epithelial compartments with impaired Ror2 signaling

ABSTRACT: Microarray analyses revealed distinct gene expression alterations in the luminal and basal epithelial compartments in the absence of Ror2 with marked alterations observed in genes associated with actin filament-based processes and the actin cytoskeletal network. Given that Ror2 expression resides in both basal and luminal epithelial cells, we wanted to identify compartment-specific functions for Ror2 in coordinating development. Accordingly, luminal and basal epithelial cell populations from shLUC and shRor2 outgrowths were isolated by FACS separation on the basis of CD24 and CD29 surface marker expression and gene expression analysis was subsequently performed using Agilent microarrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Chad Creighton   Kevin Roarty  Chad J Creighton  Jeffrey M Rosen 

PROVIDER: E-GEOD-57985 | ArrayExpress | 2015-01-09



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