Transcriptomics

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Targeting the epigenetic regulation of Hedgehog transcriptional output through BET bromodomain inhibition


ABSTRACT: Comparison of gene expression changes in Ptch-deficient mouse medulloblastoma cell line SmoWT-MB upon treatment with SMOi GDC-0449 or BETi JQ1. The hypothesis is that they can both inhibit the expressions of Hh signaling target genes in this Hh-driven tumor cell line. Total RNA from JQ1 or GDC-0449 treated SmoWT-MB cells in comparison with DMSO treated cells

ORGANISM(S): Mus musculus  

SUBMITTER: Yujie Tang  Yoon-Jae Cho    

PROVIDER: E-GEOD-58185 | ArrayExpress | 2014-06-04

SECONDARY ACCESSION(S): GSE58185PRJNA251527

REPOSITORIES: GEO, ArrayExpress

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