Transcriptomics

Dataset Information

30

MiR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a


ABSTRACT: Gene expression profiling from fine purified hematopoietic stem and progenitor cells of WT or miR-29a deletion. This anlaysis identified the up- and down-regulated genes from miR-29a deletion, and suggest that cell cycle regulators are significantly changed. The results demonstrate that the HSC lacking of miR-29a appeared as committed progentiors from their gene expression patterns. Cells are sorted into hematopoietic stem cells (HSC, Lin-c-Kit+Sca-1+Slam1+CD34-) and committed progenitor cells (Prog, Lin-c-kit+Sca-1-) with > 90% purity using FACS AriaII machine.

ORGANISM(S): Mus musculus  

SUBMITTER: Siddhartha Mukherjee  Bart d Strooper   Luisa Cimmino   James Dooley   Adrion Liston   Wenhuo Hu   Stephen S Chung   Christopher Y Park    

PROVIDER: E-GEOD-58237 | ArrayExpress| 2015-03-07

SECONDARY ACCESSION(S): GSE58237PRJNA251660

REPOSITORIES: GEO, ArrayExpress

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