Genomics

Dataset Information

297

Genome-wide analysis of histone modifications in latently HIV-1 infected T cells


ABSTRACT: The epigenetic mechanisms established by histone modifications may affect the transcriptional silencing of HIV-1 and viral latency. A systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency. In this study, histone modification profiles of HIV-1 latency cell lines were compared with those of uninfected CD4+ T cell line. The HIV-1 latency gave rise to differential histone modification regions. The differential enrichment patterns helped us to define potential effector genes leading to the viral latency. The histone H3K4me3 and H3K9ac profiles were obtained from the HIV-1 latency cell lines (NCHA1, NCHA2, and ACH2) and control CD4+ T cell line (A3.01)

ORGANISM(S): Homo sapiens  

SUBMITTER: Jihwan Park   Sung S Kim  Tae-Young Roh  Seokjin Ham  Byeong-Sun Choi  Chae H Lim 

PROVIDER: E-GEOD-58247 | ArrayExpress | 2014-06-06

SECONDARY ACCESSION(S): GSE58247SRP042974PRJNA251729

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Genome-wide analysis of histone modifications in latently HIV-1 infected T cells.

Park Jihwan J   Lim Chae Hyun CH   Ham Seokjin S   Kim Sung Soon SS   Choi Byeong-Sun BS   Roh Tae-Young TY  

AIDS (London, England) 20140701 12


OBJECTIVES: The transcriptional silencing of HIV type 1 (HIV-1) provirus in latently infected cells is a major hurdle on the pathway to HIV-1 elimination. The epigenetic mechanisms established by histone modifications may affect the transcriptional silencing of HIV-1 and viral latency. A systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency. DESIGN: The HIV-1 latency cell lines (NCHA1, NCHA2 and ACH2] were compared with CD4⁺ T  ...[more]

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