Genomics

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Genome-wide co-occupancy of Hoxa9 and C/EBPα in Hoxa9/Meis1 transformed HSCs [ChIP-seq]


ABSTRACT: Identification of the genome-wide binding sites of Hoxa9 and C/EBPα in a murine myeloblastic cell line transformed by Hoxa9/Meis1. Over 50% of Hoxa9 binding sites are co-bound by C/EBPα, providing mechanistic insight into the requirement of C/EBPα for Hoxa9-mediated leukemogenesis. Additionally, genome-wide occupancy of H3K4 monomethylation and H3K27 trimethylation provide additional information on the functionality of Hoxa9/C/EBPα cobound loci. Examination of two transcription factor binding sites and two histone modifications in a transformed cell line.

ORGANISM(S): Mus musculus  

SUBMITTER: Jay L. Hess   Jay L Hess 

PROVIDER: E-GEOD-58361 | ArrayExpress | 2014-06-11

SECONDARY ACCESSION(S): SRP043075GSE58361PRJNA252108

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis.

Collins Cailin C   Wang Jingya J   Miao Hongzhi H   Bronstein Joel J   Nawer Humaira H   Xu Tao T   Figueroa Maria M   Muntean Andrew G AG   Hess Jay L JL  

Proceedings of the National Academy of Sciences of the United States of America 20140623 27


Homeobox A9 (HOXA9) is a homeodomain-containing transcription factor that plays a key role in hematopoietic stem cell expansion and is commonly deregulated in human acute leukemias. A variety of upstream genetic alterations in acute myeloid leukemia (AML) lead to overexpression of HOXA9, almost always in association with overexpression of its cofactor meis homeobox 1 (MEIS1) . A wide range of data suggests that HOXA9 and MEIS1 play a synergistic causative role in AML, although the molecular mech  ...[more]

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