Transcriptomics

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Paradoxical neurobehavioral rescue by cues associated with infant trauma: Amygdala 5-HT and CORT


ABSTRACT: We show that infant trauma, as modeled by infant paired odor-shock conditioning, results in later life depressive-like behavior that can be modulated by learned infant cues (i.e., odor previously paired with shock). We have previously shown that this infant attachment odor learning paradigm results in the creation of a new artificial maternal odor that is able to control pup behavior and retain its value throughout development. Here, we assess the mechanism by which this artificial maternal odor is able to rescue depressive-like behavior and show that this anti-depressant like effect results in glucocorticoid and serotonin (5-HT) related changes in amygdala gene expression and is dependent on amygdala 5-HT. Furthermore, increasing amygdala 5-HT and blocking corticosterone (CORT) in the absence of odor mimics the adult rescue effects elicited by the artificial maternal odor, suggesting a mechanism by which odor presentation exerts its repair effects. There are three experimental groups: 1: pups with no infant shock and the adult forced swim test (FST)with no odor; 2. pups with infant odor-shock pairing and the adult forced swim test (FST) with no odor; 3. pups with infant odor-shock pairing and adult forced swim test with infant odor.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Regina M Sullivan   Gordon A Barr  Sheilyn Nunez  Kiseko Shio  Gordon A. Barr  Millie Rincón-Cortés 

PROVIDER: E-GEOD-58548 | ArrayExpress | 2015-02-04

SECONDARY ACCESSION(S): GSE58548PRJNA252853

REPOSITORIES: GEO, ArrayExpress

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Publications

Enduring good memories of infant trauma: rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction.

Rincón-Cortés Millie M   Barr Gordon A GA   Mouly Anne Marie AM   Shionoya Kiseko K   Nuñez Bestina S BS   Sullivan Regina M RM  

Proceedings of the National Academy of Sciences of the United States of America 20150105 3


Children form a strong attachment to their caregiver--even when that caretaker is abusive. Paradoxically, despite the trauma experienced within this relationship, the child develops a preference for trauma-linked cues--a phenomenon known as trauma bonding. Although infant trauma compromises neurobehavioral development, the mechanisms underlying the interaction between infant trauma bonding (i.e., learned preference for trauma cues) and the long-term effects of trauma (i.e., depressive-like behav  ...[more]

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