Transcriptomics

Dataset Information

61

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis


ABSTRACT: Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during an active EMT. This experiment includes a total of 12 samples consisting of 2 experimental groups at 2 matching time points (day 4, day 12), each with 3 biological repeats: 3 control empty vector samples as controls and 3 inducible TWIST1 samples as the experimental condition.

OTHER RELATED OMICS DATASETS IN: E-GEOD-54505

ORGANISM(S): Homo sapiens  

SUBMITTER: Jihye Kim   Joshua H Cabrera  Kay Huebner  Luciano Cascione  Deepika Neelakantan  Pierluigi Gasparini  David Drasin  Aik C Tan  Vadym Zaberezhnyy  Heide L Ford  Anna L Guarnieri  David J Drasin  Chu A Wang 

PROVIDER: E-GEOD-58560 | ArrayExpress | 2015-02-26

SECONDARY ACCESSION(S): GSE58560PRJNA252884

REPOSITORIES: GEO, ArrayExpress

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Publications


Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity. Recently, the process of an oncogenic EMT, followed by a reverse mesenchymal-to-epithelial transition (MET), has been implicated as critical in the metastatic colonization of carcinomas. Unlike governance of epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here, we describe and characterize the first microRNA that enhances exclusively mesenchymal program  ...[more]

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