Transcriptomics

Dataset Information

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Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing


ABSTRACT: We utilized RNA sequencing to expand and better define the molecular entities involved in the transcriptional programming within the eosphagus in eosinophilic esophagitis (EoE) Examination of differentially expressed genes from RNA sequencing data performed on esophageal biopsy specimen from 6 healthy controls and 10 patients with active EoE

ORGANISM(S): Homo sapiens  

SUBMITTER: Marc E Rothenberg   Joseph D Sherrill  Marc Rothenberg 

PROVIDER: E-GEOD-58640 | ArrayExpress | 2014-06-27

SECONDARY ACCESSION(S): SRP043388GSE58640PRJNA253059

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus that is compounded by genetic predisposition and hypersensitivity to environmental antigens. Using high-density oligonucleotide expression chips, a disease-specific esophageal transcript signature was identified and was shown to be largely reversible with therapy. In an effort to expand the molecular signature of EoE, we performed RNA sequencing on esophageal biopsies from healthy controls and patients with acti  ...[more]

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