Dataset Information


B.thetaiotaomicron or B. longum mono-association versus B. thetaiotaomicron/B. longum co-colonization, PR chow, NMRI

ABSTRACT: Genome wide transcriptional comparison of B. thetaiotaomicron or B. longum mono-association vs. B. thetaiotaomicron bi-association with B. longum. Cecal populations from 10d colonizations with NMRI gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Total RNA was prepared from cecal contents of 10 day associated gnotobiotic mice and hybridized to B. thetaiotaomicron/B. longum GeneChips.

SUBMITTER: Christina T Chen   Justin L Sonnenburg  Justin L. Sonnenburg  Jeffrey I Gordon 

PROVIDER: E-GEOD-5865 | ArrayExpress | 2010-07-01



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Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host.

Sonnenburg Justin L JL   Chen Christina T L CT   Gordon Jeffrey I JI  

PLoS biology 20061101 12

Probiotics are deliberately ingested preparations of live bacterial species that confer health benefits on the host. Many of these species are associated with the fermentation of dairy products. Despite their increasing use, the molecular details of the impact of various probiotic preparations on resident members of the gut microbiota and the host are generally lacking. To address this issue, we colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the adult human  ...[more]

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