Transcriptomics

Dataset Information

4

B.thetaiotaomicron mono-association versus B. thetaiotaomicron co-colonization with B. longum, PR chow, B6


ABSTRACT: Genome wide transcriptional comparison of B. thetaiotaomicron mono-association vs. B. thetaiotaomicron bi-association with B. longum. Cecal populations from 10d colonizations with b6 gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Total RNA was prepared from cecal contents of 10 day associated gnotobiotic mice and hybridized to B. thetaiotaomicron/B. longum GeneChips.

SUBMITTER: Christina T Chen   Justin L Sonnenburg  Justin L. Sonnenburg  Jeffrey I Gordon 

PROVIDER: E-GEOD-5866 | ArrayExpress | 2010-07-01

SECONDARY ACCESSION(S): GSE5866PRJNA104405

REPOSITORIES: GEO, ArrayExpress

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Publications

Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host.

Sonnenburg Justin L JL   Chen Christina T L CT   Gordon Jeffrey I JI  

PLoS biology 20061101 12


Probiotics are deliberately ingested preparations of live bacterial species that confer health benefits on the host. Many of these species are associated with the fermentation of dairy products. Despite their increasing use, the molecular details of the impact of various probiotic preparations on resident members of the gut microbiota and the host are generally lacking. To address this issue, we colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the adult human  ...[more]

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