Dataset Information


Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh differentiated C2C12 Myoblasts (D28hrs)

ABSTRACT: Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of 28hr differentiated myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips. Control and knock down cells were grown in differentiating conditions for 28hrs and total RNA was used to perform microarray analysis

ORGANISM(S): Mus musculus  

SUBMITTER: Deepika Puri  Mohammed Rumman   Amena Saleh   Jeeva Sellathurai   Jyotsna Dhawan   Henrik D Schroeder   Sirisha Cheedipudi   Malini S Pillai   Rakesh Mishra   Prethish Srinivas   Hardik Gala   Reety Arora    

PROVIDER: E-GEOD-58673 | ArrayExpress | 2015-08-19



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A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene.

Cheedipudi Sirisha S   Puri Deepika D   Saleh Amena A   Gala Hardik P HP   Rumman Mohammed M   Pillai Malini S MS   Sreenivas Prethish P   Arora Reety R   Sellathurai Jeeva J   Schrøder Henrik Daa HD   Mishra Rakesh K RK   Dhawan Jyotsna J  

Nucleic acids research 20150603 13

Adult stem cell quiescence is critical to ensure regeneration while minimizing tumorigenesis. Epigenetic regulation contributes to cell cycle control and differentiation, but few regulators of the chromatin state in quiescent cells are known. Here we report that the tumor suppressor PRDM2/RIZ, an H3K9 methyltransferase, is enriched in quiescent muscle stem cells in vivo and controls reversible quiescence in cultured myoblasts. We find that PRDM2 associates with >4400 promoters in G0 myoblasts, 5  ...[more]

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