Dataset Information


Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh Quiescent C2C12 Myoblasts (G0 enriched)

ABSTRACT: Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of quiescent myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips. Control and knock down cells were synchronized at G0 by suspension culture and total RNA was used to perform microarray analysis

ORGANISM(S): Mus musculus  

SUBMITTER: Deepika Puri   Mohammed Rumman  Prethish Sreenivas  Amena Saleh  Jyotsna Dhawan  Jeeva Sellathurai  Henrik D Schroeder  Sirisha Cheedipudi  Malini S Pillai  Rakesh Mishra  Hardik Gala  Reety Arora 

PROVIDER: E-GEOD-58674 | ArrayExpress | 2015-06-30



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A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene.

Cheedipudi Sirisha S   Puri Deepika D   Saleh Amena A   Gala Hardik P HP   Rumman Mohammed M   Pillai Malini S MS   Sreenivas Prethish P   Arora Reety R   Sellathurai Jeeva J   Schrøder Henrik Daa HD   Mishra Rakesh K RK   Dhawan Jyotsna J  

Nucleic acids research 20150603 13

Adult stem cell quiescence is critical to ensure regeneration while minimizing tumorigenesis. Epigenetic regulation contributes to cell cycle control and differentiation, but few regulators of the chromatin state in quiescent cells are known. Here we report that the tumor suppressor PRDM2/RIZ, an H3K9 methyltransferase, is enriched in quiescent muscle stem cells in vivo and controls reversible quiescence in cultured myoblasts. We find that PRDM2 associates with >4400 promoters in G0 myoblasts, 5  ...[more]

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