Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Iouri Chepelev
PROVIDER: E-GEOD-58775 | ArrayExpress | 2015-06-13
SECONDARY ACCESSION(S): SRP043531GSE58775PRJNA253470
REPOSITORIES: GEO, ArrayExpress, ENA
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Nature communications 20141222
Epigenetic factors have been implicated in the regulation of CD4(+) T-cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo function in T-cell differentiation remains unknown. Here we report that Jmjd3 ablation promotes CD4(+) T-cell differentiation into Th2 and Th17 cells in the small intestine and colon, and inhibits T-cell differentiation into Th1 cells under different cytokine-polarizing conditions and in a Th1-dependent colitis model. Jmjd3 deficiency also r ...[more]