Transcriptomics

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Whole blood gene expression profiling of rheumatoid arthritis patients


ABSTRACT: Approximately 30% of rheumatoid arthritis patients achieve inadequate response to anti-TNF biologics. In this study, we sought to identify a blood gene expression biomarker correlating with 12-week response to infliximab in patients with moderate to severe disease. Response was assessed using dynamic contrast-enhanced MRI imaging of the wrist. Baseline whole blood samples from 59 patients were collected as part of a placebo-controlled clinical study of infliximab in rheumatoid arthritis. Samples were profiled by Affymetrix microarray and correlation between gene expression and 12-week response was assessed. DAS28 (Disease Activity Score including a 28-joint count)

ORGANISM(S): Homo sapiens  

SUBMITTER: Kenzie D MacIsaac   Kenzie MacIsaac 

PROVIDER: E-GEOD-58795 | ArrayExpress | 2014-09-01

SECONDARY ACCESSION(S): GSE58795PRJNA253505

REPOSITORIES: GEO, ArrayExpress

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