Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA97323
ORGANISM(S): Mus musculus
SUBMITTER: Minoru S.H. Ko Shinji Masui Hitoshi Niwa Kazue Takahashi Minoru S Ko Yayoi Toyooka Alexei A Sharov Rika Yagi Akihiko Okuda Ryo Matoba Yuhki Nakatake Daisuke Shimosato
PROVIDER: E-GEOD-5895 | ArrayExpress | 2010-06-11
SECONDARY ACCESSION(S): GSE5895PRJNA97323
REPOSITORIES: GEO, ArrayExpress
Action | DRS | |||
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E-GEOD-5895.README.txt | Txt | |||
E-GEOD-5895.idf.txt | Idf | |||
E-GEOD-5895.processed.1.zip | Processed | |||
E-GEOD-5895.raw.1.zip | Raw | |||
E-GEOD-5895.raw.2.zip | Raw |
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Masui Shinji S Nakatake Yuhki Y Toyooka Yayoi Y Shimosato Daisuke D Yagi Rika R Takahashi Kazue K Okochi Hitoshi H Okuda Akihiko A Matoba Ryo R Sharov Alexei A AA Ko Minoru S H MS Niwa Hitoshi H
Nature cell biology 20070521 6
The pluripotency of embryonic stem (ES) cells is thought to be maintained by a few key transcription factors, including Oct3/4 and Sox2. The function of Oct3/4 in ES cells has been extensively characterized, but that of Sox2 has yet to be determined. Sox2 can act synergistically with Oct3/4 in vitro to activate Oct-Sox enhancers, which regulate the expression of pluripotent stem cell-specific genes, including Nanog, Oct3/4 and Sox2 itself. These findings suggest that Sox2 is required by ES cells ...[more]