Transcriptomics

Dataset Information

124

Transcription profiling of human bone marrow aspirate plasma cells from healthy Donors (N=22), MGUS (N=44), and Smoldering Myeloma (N=12)


ABSTRACT: This series represents bone marrow aspirates from smoldering multiple myeloma patients Experiment Overall Design: We analyzed arrays for plasma cells from 22 cases of healthy donors, 44 cases of MGUS, and 12 cases of smoldering myeloma

ORGANISM(S): Homo sapiens  

SUBMITTER: Shaughnessy Jr John  

PROVIDER: E-GEOD-5900 | ArrayExpress | 2008-06-14

SECONDARY ACCESSION(S): GSE5900PRJNA97327

REPOSITORIES: GEO, ArrayExpress

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Publications


Monoclonal gammopathy of undetermined significance (MGUS) can progress to multiple myeloma (MM). Although these diseases share many of the same genetic features, it is still unclear whether global gene-expression profiling might identify prior genomic signatures that distinguish them. Through significance analysis of microarrays, 52 genes involved in important pathways related to cancer were differentially expressed in the plasma cells of healthy subjects (normal plasma-cell [NPC]; n=22) and pat  ...[more]

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