Dataset Information


Transcriptome analysis of WT and ATRX KO Cast x 129 mouse ES cells

ABSTRACT: Analysis of gene expression in WT and ATRX KO Cast x 129 Mouse ES cells Paired end RNA-seq analysis of PolyA selected RNA and PolyA depeleted RNA from in both wildtype nd ATRX knocked out Castx129 Mouse ES Cells

ORGANISM(S): Mus musculus  

SUBMITTER: Hsiao P Voon   Richard Gibbons  Douglas R Higgs  Jim R Hughes  Jim Hughes 

PROVIDER: E-GEOD-59269 | ArrayExpress | 2015-04-16



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ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

Voon Hsiao P J HP   Hughes Jim R JR   Rode Christina C   De La Rosa-Velázquez Inti A IA   Jenuwein Thomas T   Feil Robert R   Higgs Douglas R DR   Gibbons Richard J RJ  

Cell reports 20150409 3

Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin and telomeres. The role of H3.3 at heterochromatic regions is unknown, but mutations in the ATRX/Daxx/H3.3 pathway are linked to aberrant telomere lengthening in certain cancers. In this study, we show that ATRX-dependent deposition of H3.3 is no  ...[more]

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