Genomics,Multiomics

Dataset Information

95

Genome-wide ChIP seq of H3.3 in WT and ATRX KO mouse ES cells


ABSTRACT: Regions of H3.3 binding in WT and ATRX KO mouse ES cells were identified by ChIP seq Chip-seq experiements were performed in WT and ATRX KO E14 mouse ES cells

ORGANISM(S): Mus musculus  

SUBMITTER: Hsiao P Voon  Jim Hughes    

PROVIDER: E-GEOD-59270 | ArrayExpress | 2015-08-19

SECONDARY ACCESSION(S): GSE59270SRP044196PRJNA254837

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

Voon Hsiao P J HP   Hughes Jim R JR   Rode Christina C   De La Rosa-Velázquez Inti A IA   Jenuwein Thomas T   Feil Robert R   Higgs Douglas R DR   Gibbons Richard J RJ  

Cell reports 20150409 3


Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin and telomeres. The role of H3.3 at heterochromatic regions is unknown, but mutations in the ATRX/Daxx/H3.3 pathway are linked to aberrant telomere lengthening in certain cancers. In this study, we show that ATRX-dependent deposition of H3.3 is no  ...[more]

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