Genomics

Dataset Information

0

Genome-wide ChIP seq of H3.3 in WT and ATRX KO mouse ES cells


ABSTRACT: Regions of H3.3 binding in WT and ATRX KO mouse ES cells were identified by ChIP seq Chip-seq experiements were performed in WT and ATRX KO E14 mouse ES cells

ORGANISM(S): Mus musculus  

SUBMITTER: Hsiao P Voon   Jim Hughes 

PROVIDER: E-GEOD-59270 | ArrayExpress | 2015-04-16

SECONDARY ACCESSION(S): GSE59270SRP044196PRJNA254837

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

Voon Hsiao P J HP   Hughes Jim R JR   Rode Christina C   De La Rosa-Velázquez Inti A IA   Jenuwein Thomas T   Feil Robert R   Higgs Douglas R DR   Gibbons Richard J RJ  

Cell reports 20150409 3


Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin and telomeres. The role of H3.3 at heterochromatic regions is unknown, but mutations in the ATRX/Daxx/H3.3 pathway are linked to aberrant telomere lengthening in certain cancers. In this study, we show that ATRX-dependent deposition of H3.3 is no  ...[more]

Similar Datasets

2015-04-16 | E-GEOD-59271 | ArrayExpress
2013-11-11 | E-GEOD-49455 | ArrayExpress
2015-04-16 | E-GEOD-59269 | ArrayExpress
2013-12-21 | E-GEOD-47492 | ArrayExpress
2015-07-15 | E-GEOD-70811 | ArrayExpress
2010-12-31 | E-GEOD-22028 | ArrayExpress
2015-01-02 | E-GEOD-64062 | ArrayExpress
2012-03-08 | E-GEOD-35339 | ArrayExpress
2013-12-21 | E-GEOD-47757 | ArrayExpress
2015-10-26 | E-GEOD-73881 | ArrayExpress