Transcriptomics

Dataset Information

4

Environmentally induced epigenetic transgenerational inheritance of ovarian disease


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Michael K Skinner  

PROVIDER: E-GEOD-59278 | ArrayExpress | 2014-07-17

SECONDARY ACCESSION(S): GSE59278PRJNA255457

REPOSITORIES: GEO, ArrayExpress

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Publications

Environmentally induced epigenetic transgenerational inheritance of ovarian disease.

Nilsson Eric E   Larsen Ginger G   Manikkam Mohan M   Guerrero-Bosagna Carlos C   Savenkova Marina I MI   Skinner Michael K MK  

PloS one 20120503 5


The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adult onset ovarian disease was assessed. Transgenerational disease phenotypes observed included an increase i  ...[more]

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