Transcriptomics,Multiomics

Dataset Information

8

Role of areca nut induced TGF-β and epithelial mesenchymal interaction in pathogenesis of precancerous Oral submucous fibrosis


ABSTRACT: To understand the role of areca nut and TGF-β induced gene expression changes in fibroblasts and its contibution in the manifestation of Oral submucous fibrosis, we studied gene expression profile in primary human gingival fibroblast (hGF) cells following treatment with areca nut, TGF-β and both together. Control Vs Areca nut 5 µg/ml water extract (5H) (2), Contro Vs TGF-β (2), Control Vs Areca nut (5 µg/ml) and TGF-β (5 ng/ml) (5H+T) (2). (2)- Biological duplicates.

OTHER RELATED OMICS DATASETS IN: PRJNA255276

ORGANISM(S): Homo Sapiens

SUBMITTER: S G Rao   Paturu Kondaiah  Neeraj Kumar  Neeraj KUMAR  Ila Pant  Imran Khan 

PROVIDER: E-GEOD-59414 | ArrayExpress | 2015-07-06

SECONDARY ACCESSION(S): GSE59414PRJNA255276

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-59414.idf.txt Idf
E-GEOD-59414.processed.1.zip Processed
E-GEOD-59414.raw.1.zip Raw
E-GEOD-59414.sdrf.txt Txt
Items per page:
1 - 4 of 4
altmetric image

Publications

Role of Areca Nut Induced TGF-β and Epithelial-Mesenchymal Interaction in the Pathogenesis of Oral Submucous Fibrosis.

Pant Ila I   Kumar Neeraj N   Khan Imran I   Rao Somanahalli Girish SG   Kondaiah Paturu P  

PloS one 20150624 6


Areca nut consumption has been implicated in the progression of Oral Submucous fibrosis (OSF); an inflammatory precancerous fibrotic condition. Our previous studies have demonstrated the activation of TGF-β signaling in epithelial cells by areca nut components and also propose a role for epithelial expressed TGF-β in the pathogenesis of OSF. Although the importance of epithelial cells in the manifestation of OSF has been proposed, the actual effectors are fibroblast cells. However, the role of a  ...[more]

Similar Datasets

2013-05-22 | E-GEOD-38227 | ArrayExpress
| E-GEOD-59414 | BioStudies
| E-GEOD-38227 | BioStudies
| S-EPMC4479469 | BioStudies
| S-EPMC3526649 | BioStudies
| S-EPMC5052620 | BioStudies
| S-EPMC8606562 | BioStudies
| S-EPMC8208015 | BioStudies
2013-01-01 | S-EPMC3689880 | BioStudies
2017-01-01 | S-EPMC5562500 | BioStudies