Dataset Information


Expression profile for BW25113 ΔmqsRA with deoxycholate stress

ABSTRACT: MqsR/MqsA is a well-characterized toxin/antitoxin system with several regulatory roles. Deletion of mqsRA reduced growth with deoxycholate stress. Here we performed a microarray to determine the expression profile with and without mqsRA under deoxycholate stress to determine transcriptional regulation. Escherichia coli K-12 BW25113 with and without mqsRA was exposed to deoxycholate stress.

ORGANISM(S): Escherichia coli BW25113  

SUBMITTER: Thomas K. Wood   Wood K Thomas  Kwan W Brian 

PROVIDER: E-GEOD-59441 | ArrayExpress | 2015-01-09



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The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress.

Kwan Brian W BW   Lord Dana M DM   Peti Wolfgang W   Page Rebecca R   Benedik Michael J MJ   Wood Thomas K TK  

Environmental microbiology 20150214 9

Toxin/antitoxin (TA) systems are ubiquitous within bacterial genomes, and the mechanisms of many TA systems are well characterized. As such, several roles for TA systems have been proposed, such as phage inhibition, gene regulation and persister cell formation. However, the significance of these roles is nebulous due to the subtle influence from individual TA systems. For example, a single TA system has only a minor contribution to persister cell formation. Hence, there is a lack of defining phy  ...[more]

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