Transcriptomics,Genomics

Dataset Information

298

Polycomb PRC2 antagonizes de novo DNA methylation at the maternal Gtl2-Rian-Mirg locus [Next-Gen Sequence Data]


ABSTRACT: Wild-type mouse embryonic stem cells are compared with mutants for components of PRC2 including Ezh2-/-, Eed-/-, and Jarid2-/- cells. Chromatin modifications, Gene expression, Pol-II, small-RNA sequencing, and DNA methylation are compared for both cell types. To study genomic and epigentic control of PRC2 in mESCs, we designed gene expression analysis (RNA-Seq and small RNA-Seq), combining with ChIP-Seq analysis of several factors and histone marks from wild-type and distinct PRC2 mutants including wild-type, Ezh2-/-, Eed-/-, and Jarid2-/-.

ORGANISM(S): Mus musculus  

SUBMITTER: David A Hendrix   Partha P Das  David Hendrix 

PROVIDER: E-GEOD-59463 | ArrayExpress | 2015-07-15

SECONDARY ACCESSION(S): SRP044364GSE59463PRJNA255385

REPOSITORIES: GEO, ArrayExpress, ENA

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