Transcriptomics

Dataset Information

17

DNA methylome analysis in infants from The Gambia / Aflatoxin / Seasonality study


ABSTRACT: Genome wide DNA methylation profiling in infant's blood from a mother/child cohort in The Gambia. The main variables of the analyses were the intra-uterine exposure to aflatoxin B1 (AFB1) and the season of conception. The Illumina Infinium HumanMethylation 450k Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in whole peripheral blood obtained at 3-6 months of age. A total of 124 samples were analysed, including 3 technical replicates. Bisulphite converted DNA from the 124 samples were hybridised to the Illumina Infinium HumanMethylation 450k Beadchip

ORGANISM(S): Homo sapiens  

SUBMITTER: Matt Silver   Hector Hernandez-Vargas 

PROVIDER: E-GEOD-59592 | ArrayExpress | 2015-04-18

SECONDARY ACCESSION(S): GSE59592PRJNA255668

REPOSITORIES: GEO, ArrayExpress

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Publications


Exposure to environmental toxins during embryonic development may lead to epigenetic changes that influence disease risk in later life. Aflatoxin is a contaminant of staple foods in sub-Saharan Africa, is a known human liver carcinogen and has been associated with stunting in infants.We have measured aflatoxin exposure in 115 pregnant women in The Gambia and examined the DNA methylation status of white blood cells from their infants at 2-8 months old (mean 3.6 ± 0.9). Aflatoxin exposure in women  ...[more]

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