Dataset Information


MiRNA expression of whole hippocampus 24hr post-injury in rat

ABSTRACT: Traumatic brain injury dysregulates microRNA expression in the brain. We hypothesized that injury-induced epigenetic changes contribute to neurodegeneration and learning and memory deficits after TBI. These changes may provide a mechanistic explanation for neuropsychiatric comorbidities in TBI patients. Our objective is to compare and contrast the effects of several neuroprotective drugs (JM6, PMI-006 and E33-estrogen) on the TBI-induced changes in microRNA expression in the hippocampus, a region of the brain that is critical for learning and memory. We will also study if different neuroprotective drugs have similar effects on common microRNAs which may cooperatively regulate a common set of gene targets. 3 biological samples each of Naïve, Sham control, TBI and TBI plus JM6, TI plus PMI-006, and TBI plus E33 rat hippocampi were obtained 24 hr post-sham injury or TBI, stored in RNA later and sent to GenUs Biosystems for microRNA microarray analysis.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Helen L Hellmich   Michael T Falduto  Deborah K Boone  Michael Falduto  Min Bi  Karen E Torres  Harris Weisz 

PROVIDER: E-GEOD-59646 | ArrayExpress | 2015-01-08



Similar Datasets

2015-01-08 | E-GEOD-59645 | ArrayExpress
2012-12-23 | E-GEOD-31357 | ArrayExpress
| GSE31357 | GEO
2012-09-06 | E-MTAB-795 | ArrayExpress
2020-02-15 | E-MTAB-8765 | ArrayExpress
| GSE102014 | GEO
2013-04-12 | E-GEOD-45997 | ArrayExpress
2014-06-14 | E-GEOD-58483 | ArrayExpress
2015-10-26 | E-GEOD-62760 | ArrayExpress
2010-12-20 | E-GEOD-16735 | ArrayExpress