Transcriptomics

Dataset Information

0

RNA editing by ADAR1 is essential for erythropoiesis [array]


ABSTRACT: Erythroid progenitors purified from EpoRCreR26eYFPADAR1fl/- and EpoRCreR26eYFPADAR1fl/+ control mice were compared for global gene array profiles Each sample was purified from one mouse

ORGANISM(S): Mus musculus  

SUBMITTER: J C Hartner   A M Chalk  S H Orkin  B J Liddicoat  J Lu  Alistair Morgan Chalk  C R Walkley 

PROVIDER: E-GEOD-59664 | ArrayExpress | 2016-07-24

SECONDARY ACCESSION(S): GSE59664PRJNA255900

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications


Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-restricted deletion of Adar1, we demonstrate that ADAR1 is dispensable for myelopoiesis but is essential for normal erythropoiesis. Adar1-deficient erythroid cells display a profound activation of inn  ...[more]

Similar Datasets

2015-01-29 | E-GEOD-63939 | ArrayExpress
2016-07-24 | E-GEOD-71047 | ArrayExpress
2015-07-01 | E-GEOD-46861 | ArrayExpress
2015-07-01 | E-GEOD-46929 | ArrayExpress
2013-03-28 | E-GEOD-38742 | ArrayExpress
2014-01-13 | E-GEOD-30406 | ArrayExpress
2013-09-24 | E-GEOD-43730 | ArrayExpress
2014-01-21 | E-GEOD-39457 | ArrayExpress
2013-01-17 | E-GEOD-43496 | ArrayExpress
2012-12-27 | E-GEOD-30407 | ArrayExpress