Transcriptomics,Multiomics

Dataset Information

2

Gene expression in the GWAT of ob/ob and ob/ob/Fsp27-/- mice


ABSTRACT: GWAT store most of the TAG in mice, ob/ob mice is an obese mice. Ob/ob/Fsp27-/- mice are lean when compared with ob/ob mice. The GWAT weight was dramatically reduced in ob/ob/Fsp27-/- mice. We next extract the total RNA from the GWAT of ob/ob and ob/ob/Fsp27-/- mice, to perform microaary analysis using Mouse Genome 430 2.0 arrays, Affymetrix. We then analysised the up-regulated and down regulated pathways. We extract the RNA of GWAT from 4 month old mice and hybridization on Affymetrix microarrays. We then analysis the data.

OTHER RELATED OMICS DATASETS IN: PRJNA256296

ORGANISM(S): Mus musculus  

SUBMITTER: Xiayu Xia   Linkang Zhou 

PROVIDER: E-GEOD-59807 | ArrayExpress | 2015-04-17

SECONDARY ACCESSION(S): GSE59807PRJNA256296

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-59807.idf.txt Idf
E-GEOD-59807.processed.1.zip Processed
E-GEOD-59807.raw.1.zip Raw
E-GEOD-59807.sdrf.txt Txt
Items per page:
1 - 4 of 4
altmetric image

Publications


Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, 'browning' of white fat and a healthy metabolic profile, whereas a patient with congenital CIDEC deficiency manifested an adverse lipodystrophic phenotype. Here we reconcile these data by showing that exposing Fsp27-null mice to a substantial energetic stress by crossing them with ob  ...[more]

Similar Datasets

2018-04-18 | GSE100989 | GEO
2013-01-01 | S-EPMC3774698 | BioStudies
2016-01-01 | S-EPMC5054357 | BioStudies
1000-01-01 | S-EPMC6107583 | BioStudies
2016-01-01 | S-EPMC4698064 | BioStudies
1000-01-01 | S-EPMC6172200 | BioStudies
| PRJNA552807 | ENA
2016-01-01 | S-EPMC4976857 | BioStudies
2018-01-01 | S-EPMC6138368 | BioStudies
2014-01-01 | S-EPMC4157804 | BioStudies