Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA256296
ORGANISM(S): Mus musculus
SUBMITTER: Xiayu Xia Linkang Zhou
PROVIDER: E-GEOD-59807 | ArrayExpress | 2015-04-17
SECONDARY ACCESSION(S): GSE59807PRJNA256296
REPOSITORIES: GEO, ArrayExpress
Action | DRS | |||
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E-GEOD-59807.idf.txt | Idf | |||
E-GEOD-59807.processed.1.zip | Processed | |||
E-GEOD-59807.raw.1.zip | Raw | |||
E-GEOD-59807.sdrf.txt | Txt |
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Zhou Linkang L Park Shi-Young SY Xu Li L Xia Xiayu X Ye Jing J Su Lu L Jeong Kyeong-Hoon KH Hur Jang Ho JH Oh Hyunhee H Tamori Yoshikazu Y Zingaretti Cristina M CM Cinti Saverio S Argente Jesús J Yu Miao M Wu Lizhen L Ju Shenghong S Guan Feifei F Yang Hongyuan H Choi Cheol Soo CS Savage David B DB Li Peng P
Nature communications 20150107
Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, 'browning' of white fat and a healthy metabolic profile, whereas a patient with congenital CIDEC deficiency manifested an adverse lipodystrophic phenotype. Here we reconcile these data by showing that exposing Fsp27-null mice to a substantial energetic stress by crossing them with ob ...[more]