Genomics

Dataset Information

3

Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Daniel Salomon  

PROVIDER: E-GEOD-59860 | ArrayExpress | 2015-01-20

SECONDARY ACCESSION(S): GSE59860PRJNA256914

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-59860.hyb.sdrf.txt Txt
E-GEOD-59860.idf.txt Idf
E-GEOD-59860.processed.1.zip Processed
E-GEOD-59860.processed.2.zip Processed
E-GEOD-59860.raw.1.zip Raw
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Publications

Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.

Komori H Kiyomi HK   Hart Traver T   LaMere Sarah A SA   Chew Pamela V PV   Salomon Daniel R DR  

Journal of immunology (Baltimore, Md. : 1950) 20150109 4


Memory T cells are primed for rapid responses to Ag; however, the molecular mechanisms responsible for priming remain incompletely defined. CpG methylation in promoters is an epigenetic modification, which regulates gene transcription. Using targeted bisulfite sequencing, we examined methylation of 2100 genes (56,000 CpGs) mapped by deep sequencing of T cell activation in human naive and memory CD4 T cells. Four hundred sixty-six CpGs (132 genes) displayed differential methylation between naive  ...[more]

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