Dataset Information


Gene expression profiling of preneoplastic Lgr5-creERT2/PIK3CAH1047R mammary subsets

ABSTRACT: This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from Lgr5-creERT2/PIK3CA H1047R mice Mammary cell subpopulations were isolated from Lgr5-creERT2/PIK3CA H1047R and Lgr5-creERT2 control animals 4 weeks after activation of PIK3CA H1047R transgene expression by Tamoxifen injection. Pooled mammary glands of 2-3 estrus-synchronized mice per genotype were sorted in 3 independent sortings and used for microarray analysis (24 samples in total).

ORGANISM(S): Mus musculus  

SUBMITTER: Shany Koren   Tim Roloff  Stephane Thiry  Mohamed Bentires-Alj 

PROVIDER: E-GEOD-59870 | ArrayExpress | 2015-08-12



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The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative potential. A key issue in breast cancer biology is the effect of genomic lesions in specific mammary cell lineages on tumour heterogeneity and progression. The impact of transforming events on fate conversion in cancer cells of origin and thus their contribution to tumour heterogeneity r  ...[more]

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