Transcriptomics

Dataset Information

2

Bedaquiline-induced transcriptional response of Mycobacterium smegmatis mc2 155


ABSTRACT: Transcriptional profiling of M. smegmatis mc2155 grown on Hartmans de Bont (HdB) supplemented with 0.2% glycerol and 0.05% Tween80 challenged with 2 μg/ml Bedaquiline and Dimethyl sulfoxide (DMSO) Two-condition experiment. Biological replicates: 5 independently grown and harvested. One replicate per array.

SUBMITTER: Gregory M Cook   Jennifer R Robson 

PROVIDER: E-GEOD-59871 | ArrayExpress | 2015-04-06

SECONDARY ACCESSION(S): GSE59871PRJNA256964

REPOSITORIES: GEO, ArrayExpress

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Publications

Bactericidal mode of action of bedaquiline.

Hards Kiel K   Robson Jennifer R JR   Berney Michael M   Shaw Lisa L   Bald Dirk D   Koul Anil A   Andries Koen K   Cook Gregory M GM  

The Journal of antimicrobial chemotherapy 20150308 7


It is not fully understood why inhibiting ATP synthesis in Mycobacterium species leads to death in non-replicating cells. We investigated the bactericidal mode of action of the anti-tubercular F1Fo-ATP synthase inhibitor bedaquiline (Sirturo™) in order to further understand the lethality of ATP synthase inhibition.Mycobacterium smegmatis strains were used for all the experiments. Growth and survival during a bedaquiline challenge were performed in multiple media types. A time-course microarray w  ...[more]

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