Dataset Information


Gene expression profiling of Lgr5-creERT2/PIK3CA H1047R and K8-creERT2/PIK3CA H1047R-evoked mammary tumors

ABSTRACT: This study examined the gene expression profile of mammary tumors derived from Lgr5- and K8-positive cell-of-origins Mammary tumors and reference mammary glands from control mice were collected, cryo-homogenized, total RNA was isolated and analyzed by microarray (total 25 samples).

ORGANISM(S): Mus musculus  

SUBMITTER: Joana Pinto do Couto   Shany Koren  Tim Roloff  Stephane Thiry  Mohamed Bentires-Alj 

PROVIDER: E-GEOD-59872 | ArrayExpress | 2015-08-12



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The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative potential. A key issue in breast cancer biology is the effect of genomic lesions in specific mammary cell lineages on tumour heterogeneity and progression. The impact of transforming events on fate conversion in cancer cells of origin and thus their contribution to tumour heterogeneity r  ...[more]

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