Transcriptomics

Dataset Information

3

PIK3CA(H1047R)-evoked breast tumorigenesis


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Tim Roloff  

PROVIDER: E-GEOD-59874 | ArrayExpress | 2015-08-12

SECONDARY ACCESSION(S): GSE59874PRJNA256957

REPOSITORIES: GEO, ArrayExpress

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Publications


The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative potential. A key issue in breast cancer biology is the effect of genomic lesions in specific mammary cell lineages on tumour heterogeneity and progression. The impact of transforming events on fate conversion in cancer cells of origin and thus their contribution to tumour heterogeneity r  ...[more]

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