Transcriptomics

Dataset Information

41

IL-8 Confers Acquired Resistance to EGFR Inhibitors through Regulating Stem Cell-like Properties in Lung Cancer


ABSTRACT: Previous study has demonstrated that PC9/gef cells are resistant to gefitinib-induced aspoptosis. To investigate the regulators contributed to gefitinib resistance in lung cancer, we analyzed the gene expression profiles between PC9 and PC9/gef cells. Our results showed that IL-8 contributes to gefitinib resistance and cancer stemness. In contrast, IL-8 knockdown decreased stem-like characteristics and increased gefitinib-induced apoptosis in PC9/gef cells. RNAs extracted from gefitinib-sensitive PC9 cells and gefitinib-resistant PC9/gef cells were hybridized on Affymetrix microarrays. We tried to compare the differential gene expression profiles between PC9 and PC9/gef cells to identify the possible regulators in gefitinib resistance.

ORGANISM(S): Homo sapiens  

SUBMITTER: Meng-Feng Tsai  Jin-Yuan Shih   Shang-Gin Wu   James C Yang   Hsuan-Yu Chen   Tzu-Hua Chang   Yi-Nan Liu   Sung-Liang Yu    

PROVIDER: E-GEOD-60189 | ArrayExpress | 2015-08-19

SECONDARY ACCESSION(S): GSE60189PRJNA257715

REPOSITORIES: GEO, ArrayExpress

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