Transcriptomics

Dataset Information

9

A systems approach identifies networks and genes linking sleep and stress: implications for neuropathology


ABSTRACT: Sleep dysfunction and stress susceptibility are co-morbid complex traits, which often precede and predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multi-level organizations of genetic landscape, candidate genes, and molecular networks associated with 328 stress and sleep traits in a chronically stressed population of 338 (C57BL/6J×A/J) F2 mice. We constructed striatal gene co-expression networks, revealing functionally and cell-type-specific gene co-regulations important for stress and sleep. Using a composite ranking system, we identified network modules most relevant for 15 independent phenotypic categories, highlighting a mitochondria/synaptic module that links sleep and stress. The key network regulators of this module are overrepresented with genes implicated in neuropsychiatric diseases. Our work suggests the interplay between sleep, stress, and neuropathology emerge from genetic influences on gene expression and their collective organization through complex molecular networks, providing a framework to interrogate the mechanisms underlying sleep, stress susceptibility, and related neuropathology. Examination of genomic and transcriptomic networks in a random subset of 100 (B6xA/J)F2 mice modeling the natural spectrum of stress susceptibility.

ORGANISM(S): Mus musculus  

SUBMITTER: Joseph Scarpa   Bojan Losic  Peng Jiang 

PROVIDER: E-GEOD-60312 | ArrayExpress | 2015-01-08

SECONDARY ACCESSION(S): GSE60312SRP045426PRJNA258009

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-60312.additional.1.zip Other
E-GEOD-60312.idf.txt Idf
E-GEOD-60312.sdrf.txt Txt
Items per page:
1 - 3 of 3

Similar Datasets

2012-06-30 | E-GEOD-36868 | ArrayExpress
2015-01-01 | S-EPMC4797932 | BioStudies
2016-01-01 | S-EPMC4938493 | BioStudies
2010-12-29 | E-GEOD-26350 | ArrayExpress
2020-01-01 | S-EPMC7574991 | BioStudies
2011-01-01 | S-EPMC3237718 | BioStudies
2014-01-01 | S-EPMC4112017 | BioStudies
2016-02-16 | E-GEOD-77908 | ArrayExpress
2016-02-16 | E-GEOD-77907 | ArrayExpress
2016-02-16 | E-GEOD-77906 | ArrayExpress