Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Yuanxin Xi Wei Li Hong Wen Xiaobing Shi
PROVIDER: E-GEOD-60366 | ArrayExpress | 2014-12-11
SECONDARY ACCESSION(S): GSE60366SRP045459PRJNA258101
REPOSITORIES: GEO, ArrayExpress, ENA
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Cell 20141001 3
The recognition of modified histones by "reader" proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here, we show that the AF9 YEATS domain binds strongly to histone H3K9 acetylation and, to a lesser extent, H3K27 and H3K18 acetylation. Crystal structural studies revealed that AF9 YEATS adopts an eight-stranded immunoglobin f ...[more]