Transcriptomics

Dataset Information

4

Analysis of therapeutic miRNA against KRAS mutant colorectal cancer


ABSTRACT: We compared the profile of miRNAs expressed in HEK293 and MRC5 cells that overexpressed KRASG12V to those expressed in parental cells that harbored wild-type KRAS. The results indicated that a subset of miRNAs was significantly down-regulated in KRASG12V transfected two cells. To address the functional relevance of miRNAs in KRAS mutant cancers, we transfected exogenous KRASG12V into HEK293 and MRC5 cells with wild type KRAS genes, and we comprehensively profiled the dysregulated miRNAs.

ORGANISM(S): Homo sapiens  

SUBMITTER: H Yamamoto   Satoshi Kondo  M Hiraki 

PROVIDER: E-GEOD-60370 | ArrayExpress | 2015-09-01

SECONDARY ACCESSION(S): GSE60370PRJNA258123

REPOSITORIES: GEO, ArrayExpress

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