Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Thomas Baumert Catherine Schuster
PROVIDER: E-GEOD-60374 | ArrayExpress | 2015-05-22
SECONDARY ACCESSION(S): GSE60374PRJNA258133
REPOSITORIES: GEO, ArrayExpress
Cell 20141101 5
Fighting viral infections is hampered by the scarcity of viral targets and their variability, resulting in development of resistance. Viruses depend on cellular molecules-which are attractive alternative targets-for their life cycle, provided that they are dispensable for normal cell functions. Using the model organism Drosophila melanogaster, we identify the ribosomal protein RACK1 as a cellular factor required for infection by internal ribosome entry site (IRES)-containing viruses. We further ...[more]